A novel family of (1-aminoalkyl)(trifluoromethyl)- and -(difluoromethyl)phosphinic acids – analogues of α-amino acids

• Natalia V. Pavlenko,
• Tatiana I. Oos,
• Yurii L. Yagupolskii,
• Igor I. Gerus,
• Uwe Doeller and
• Lothar Willms

Beilstein J. Org. Chem. 2014, 10, 722–731, doi:10.3762/bjoc.10.66

• , alanine, valine, proline, aminomalonic and aspartic acids were thus prepared. Three-component one-pot reactions of (trifluoromethyl)phosphinic acid and dibenzylamine with aldehydes were also tested to prepare the title compounds. Keywords: (1-aminoalkyl)phosphinic acids; ethyl (difluoromethyl)phosphinate

• the GABAB receptor [18]. In light of the above and in connection with our interest in the chemistry of fluorinated compounds of phosphorus we report here the preparation of a series of novel (1-aminoalkyl)phosphinic acids bearing CF3 or CHF2 groups at phosphorus. Results and Discussion Research

• to the activated C=C double bond of malonate 38 followed by hydrolysis and decarboxylation to generate adduct 39 in two steps (Scheme 10). Conclusion In conclusion, we have presented a variety of approaches to novel fluorinated (1-aminoalkyl)phosphinic acids starting from the appropriate fluorinated